The blame for the obesity epidemic has been placed on everything from genetics to poor eating . . . but is there a darker, unspoken human need that remains unfulfilled and often even unknown even to oneself? Let’s start this part of our transformative inquiry by being honest with ourselves, confronting the sabotages, finding ourselves, and then not losing that person again.

​ Unmet emotional (and spiritual) longings are recurrently filled by food, yet the longing and emptiness remain.  Our mind, in its ultimate judgment, feels empty, lonely, starved for affection or belonging recurrently and unconsciously, even telling our bodies to turn to food to gain some feeling of being “full.” 

Food eventually becomes a learned substitution for every need in our lives, including how to deal with stress, loss, grief, loneliness, and loss of faith. Stress alone comes with its own sad story of fat hormones and carbohydrate intolerance, which may lead to sleep issues. Lack of adequate sleep, in turn, contributes to “fatness.” 

Constantly, almost like a mouse on a wheel, we try and try but get nowhere. Miraculously, if goals are met, the weight is lost – think . . . just how permanent is it? Usually, not very. It is because the elephant in the room, our heart, our soul, is still in the room unattended, unfulfilled, and even unrecognized.

Is it feasible to expect that with growing awareness of these other barriers to long-term weight-loss success, a separate treatment plan would blossom out of a need for permanent wellness success?

Oh, Where to Begin to Find Such Secrets to Be Solved?

Both the logical and exercise science points of view determine that obesity is caused by energy input being greater than energy output. Many people’s palates and brains are addicted to high salt, sugar, and fatty food, true. This notion is also consistent with science, but I believe other etiologies with more effective approaches are out there but underutilized, as just discussed. 

 Humans are emotional creatures, and there is no denying basic instincts such as finding community, love, pleasure, and happiness. Unlike our land and sea mammals, which are driven biologically to reproduce and survive, humans have an expansive consciousness with the free will to choose how they want to live.

 The gift of choice without knowledge sometimes harms our overall balance and well-being. It can be argued that over the years, families have changed, giving birth to an entire generation with prominent negative health behaviors.

 If a child grows up eating fast food and drinking soda in replacement for water, the child will grow up into an adult who passes these behaviors and unhealthy ways of coping down to his/her family. Simply put, what science and psychology say about obesity is true, and an integrative approach to this problem must be taken globally. No longer can feelings, anger, stress, sexual dysfunctions in marriages or relationships/break-ups – no longer can they be ignored and swept under the rug.

 The underlying causes of obesity are driven by emotions, which then become akin to an addiction caused by the release of hormones and neurotransmitters in the body. Many food chemists, for example, design food to become addictive, which plays into the role of overeating. It’s a vicious cycle that takes time to retrain the body and brain.

 This is a huge job and one that is not being done in its entirety in any weight loss program today.
 
Plan For Listening to the Inner Self, Your Emotions, Your Beliefs
 
For many obese people, they have “lost” their power somewhere on their journey in life. Many keep giving their power away to their boss, spouse, children, friends, or anyone who needs their service. Those who have power but still struggle emotionally are stuck in belief systems that they can’t be or look a certain way.

 This, too, is linked subconsciously to being powerless.  Many experience the domino effect. Sometimes it starts with one scenario that leads into other and more complex situations later in life. 

Many who have been verbally, physically, or sexually abused in the past are likely to fall into negative eating habits. Mostly, with women, there is either an underlying sense of shame or the need to be unattractive to men. I have found this with women who were sexually abused in their upbringing. In fact, they cover and hide any sense of beauty and love that can shine from their power center. 

  People are obese for many reasons, but those who are not emotionally happy often seek fulfillment and validation through overeating. Those who “MUST eat their ice cream every day” have connected a certain food with a certain feeling. Why is this connection to a certain food that important? Questions like these must be asked and answered with a plan for emotional fulfillment without the use of food. 

A truly balanced person never has a biological urge to “need” a certain daily food for survival.  The most important lesson is that power must be balanced. Those who have excess power often abuse their personal strength.

 Or they use their power to compensate for something else lacking in their life.  Not everybody has emotional problems, but for many, the emotion is deeply buried and allows others to control our lives instead of ourselves. Even if a person is religious, he or she may not be spiritually fulfilled and in control of his or her life, choices, and emotions. 
 
Start by listening:

1. Ask yourself, are you hungry in your stomach? Is it rumbling and growling? Or, is it just a craving coming from your mind?
2. Sit quietly. Observe your thoughts and the feelings from your body. Do you feel loved? Or is there an emptiness inside?
3. What do you think of when you think of death? Do you have faith? Or do you feel all alone?
4. Do you catch yourself talking yourself out of doing what is healthy by making excuses for yourself – like, you deserve that, you’ve been “good” all day?
5. Learn to identify those “comfort foods” that your momma gave you to fix all your problems and write down suitable low-calorie replacements.

Once you have learned to listen, you should have learned quite a bit. After you identify your barriers to success, you need to develop a plan for every sabotage, and you should be ready to implement that plan without hesitation as you head for the cupcake cupboard.

©Kathryn Shattler, Synergetics Weight Loss for Life Plan
​

Hitting a weight loss plateau is typical for any low-calorie meal plan you may be following. It is a notorious roadblock for anyone wanting to lose weight, and the game plan is to succeed on that weight loss plan, be it keto or other. Here are ten reasons why you may be hitting a plateau while trying to follow a keto diet:

1. You are not keeping and maintaining a food journal. Regardless of the meal plan you follow, a food journal not only helps you stay on track with your prescribed macronutrients and calories, but it is a tremendous educational tool as well. It can teach you where your carbs and calories are coming from, how portion sizes make a huge difference in the big picture, and how to choose foods most appropriate for your goals. If you are working with a coach, the coach can use it individualize nutrition education on better choices. 

One study found that people who tracked everything they ate lost twice the amount of weight as those who did not follow what they ate.

1. You aren't supporting your healthy gut bacteria. Come on. You have all heard of the healthy microbiome! Our digestive system is home to some of the most metabolically active bacteria alive, and it can be good bacteria or harmful bacteria. So, how are you supporting your microbiome?

 

• Try adding sauerkraut, kimchi, and kefir to even the strictest keto diet to boost those helpful bacteria. Then, there are always probiotic supplements. With probiotic supplements, make sure you follow refrigeration recommendations as these are live organisms and need food safety precautions to survive in a healthy environment.

1. You are eating too many calories or protein. It is easy to consume 3,000 calories a day by binging on nuts and other high-fat foods on a keto diet. You cannot be in dietary ketosis if your calories are too high, as the body does not need to burn its own fat. It is getting all of its energy from your diet.
2. You are grazing throughout your day. Eating too frequently, even on legal keto foods, can stall fat loss. Try intermittent fasting instead. And intermittent fasts can be done without expensive research-backed programs. 
3. You aren't keeping your carb intake low enough. Many programs profess to be ketogenic, but to be genuinely ketogenic, a restriction of no more than 50 grams, about 5% carb calories, per day is recommended. To calculate the macronutrients to individualize your diet, you figure your total calorie needs minus the number of calories per day to lose weight (500 calories per day to lose 1 lb. per week on average) and then times it by .05 (5%). Then divide by four calories per gram, and that will give you your total carb allowance for the day on a 5% carb diet. That means that 20% will be protein, and 75% will be fat. It is, admittedly, a difficult diet to follow and one that should not be followed for any length of time unless medically indicated.
4. You are stressed out. Not controlling the daily stresses of a life well or dealing with major unexpected stressors can leave you with an elevated cortisol level, which alters carbohydrate metabolism. Often, meditation, mindful living, and Ashwagandha tea/supplements will help you get that cortisol down and help you control your stress more positively.
5. You aren't eating enough fiber. Dietary fiber keeps you full longer and creates an environment conducive to weight loss, particularly certain strains of bacilli. Fiber is traditionally found in high carb food such as the grain and starchy vegetable list but getting sufficient fiber on a keto diet is still essential for your health. Try eating more leafy green vegetables, cruciferous vegetables (broccoli, cauliflower, cabbage), avocado, and berries.
6. You are eating foods you are either allergic to or sensitive to. Gluten, artificial sweeteners, and other restrictive ingredients may trigger an allergic flare up and, thus, a state of inflammation. These foods can also cause dysbiosis, leaky gut syndrome, and insulin resistance, all things that can stall weight loss.
7. You are drinking too much coffee. Too much coffee may induce insulin resistance, making weight loss difficult. Too much coffee is generally more than 3 cups per day. Try ginseng tea instead and take advantage of the catechins and natural antioxidants.
8. You are neglecting restful sleep and other positive lifestyle factors such as activity and exercise. How you live dramatically affects weight loss. How you think and behave may also affect weight loss. For many patients, a good sleep regimen may break the plateau. To get adequate sleep, avoid eating late at night, avoid caffeine at least 3 hours before bedtime, resistant cases may benefit from 3-5 mg. of melatonin at bedtime, turn off all lights including computer screens, and plan on getting 7 hours of good restful sleep. Less than seven is not enough, and ten or more is too much. Balance in life. Plan on an exercise program that takes up 150 minutes per day at a minimum and is a combination of strength training and cardiovascular. Plan your carb snacks around exercise.

Remember, hitting a plateau is normal. Breaking the plateau can be tricky, but the suggestions above may help break that plateau, at least on the keto diet. Some of the points are generic and apply to any diet, such as lifestyle and stress factors.

What is the best keto diet, you ask? The keto Mediterranean Diet is the healthiest keto diet plan to follow. It has healthy fats that won't clog up your arteries, and it's good for your heart.
​
So, don't give up. Plan for the plateaus!
 

Most people have heard of type I and type II diabetes, but what about the other three types? Prediabetes, Type 1.5, and Type 3 Diabetes are all common metabolic abnormalities, but little reference is made to them in the clinical setting. So, let us take a peek at these mysterious “lurkers” behind the metabolic curtains!

Prediabetes
While many people look at this diagnosis as just a warning sign of an impending problem, it is actually far more serious than that. If you are at the prediabetes stage, the insulin resistance that got you there has been going on far too long, and the longer it has been rampant in your body, the more damage it may have done.

Prediabetes is diagnosed when your blood sugar is ≥100-125 or the HbA1C is 5.7-6.4%. There may or may not be symptoms at this point. Treatment usually consists of weight management and lifestyle medicine. Occasionally a patient is started on metformin to decrease the chances of progression to type 2 diabetes.

Functional medicines used in place of conventional medications may include recommendations for the herbal extract berberine at 500 mg three times a day or a combination of Banaba, fenugreek, cinnamon, Gymnema, magnesium, ginseng, or white mulberry.

The best thing to do if you find yourself prediabetic is to find a functional medicine doctor who can probe into the why’s of how the insulin resistance got started in the first place. Once the source of the problem can be found and treated, the symptoms will disappear.

Diabetes 1.5
This form of diabetes is thought to be autoimmune in nature and is a combination of type 1 and type 2 in its features. Latent autoimmune diabetes, also known as LADA, is a type of slowly progressing type 1 diabetes with the body slowly losing its ability to produce insulin and not requiring it pharmacologically for several months to years after diagnosis.

People with LADA are often over 30, and since their body is still producing some insulin, they are frequently misdiagnosed as diabetes type 2.  According to a journal article from Diabetic Medicine, “around 4%-14 % of patients classified with type 2 diabetes have "DAA” or diabetes-associated antibodies characteristic of LADA. Diagnosis can be confirmed by the presence of one of two autoantibodies in the blood of the patient and a low to normal C-peptide level and a progressive loss of pancreatic beta-cell activity.

Initially, LADA can be controlled with diet and exercise, but eventually, insulin shots will be necessary. Patients with LADA should be treated with insulin as the first choice as opposed to oral hypoglycemics when diet and exercise fail to control the blood sugar. Sulfonylureas should not be used as they will increase the rate of C-peptide degradation.

Treatments that may preserve beta-cell function include dipeptidyl peptidase-4 or DPP-4 inhibitors and glucagon-like peptide 1 or GLP-1 receptor agonists.

Diabetes Type 3
Currently, there is a rapid growth in the literature pointing toward insulin deficiency and insulin resistance as mediators of Alzheimer's Disease (AD)-type neurodegeneration, but this surge of new information is riddled with conflicting and unresolved concepts about the relationship between diabetes type 2, obesity and metabolic syndrome.

Type 2 diabetes causes brain insulin resistance, oxidative stress, and cognitive impairment, but its aggregate effects fall far short of mimicking AD; AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and type 2 diabetes.

Type 2 diabetes may not be sufficient to cause AD, although it could serve as a cofactor in its pathogenesis or progression. However, data referring to AD as type 3 diabetes is justified because the fundamental molecular and biochemical abnormalities overlap with type 1 diabetes and type 2 diabetes rather than mimic the effects of either one.
 
The field of diabetology is growing as we understand more about the molecular and biochemical nature of diabetes.

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​#Alzheimer'sDisease #Diabetes #Prediabetes 

Ketogenic diets are all the rage today, many of them followed incorrectly or at risk to their heart’s health. If you have a coach helping you with this diet, look to see if they are certified in the diet instruction. Certification programs exist that guide the provider in helping the patient or client choose heart-healthy fats when keeping that fat goal high and not turn to a diet of bacon and eggs.

The five types of keto diets people are following these days are:

The Standard Keto Diet
This diet is the most typical ketogenic diet and consists of a 75% fat intake, 20% protein intake, and 5% carbohydrate intake. It is necessary to control the protein intake because protein readily turns into glucose. It is no joke that this diet is strict and difficult to follow.
​
Some good examples of healthier fat choices include:
1. Cacao Butter
2. Coconut Butter
3. Organic Coconut Oil
4. MCT Oil
5. Almond
6. Butter
7. Coconut Milk
8. Coconut Cream
9. Ghee
10. Avocado
11. Nuts
12. Sugar Free Chocolate
13. Olives
14. Butter
15. Avocado Oil
16. Cheeses
17. Olive Oil

Targeted Keto Diet
Targeted Ketogenic Diets (TKD) are geared toward bodybuilders. With a targeted keto, allowable carbohydrates are scheduled into the meal plan a half hour before a workout. The key to making this diet a success is high- intensity workouts to get that glucose burned out of the system before it is taken out of ketosis.

A good tip for burning your allowable carbs fast is to eat easily digestible carbohydrates. After the workout, it is essential to take in more protein to rebuild muscle fast.

Cyclical Keto Diet
This variation of the standard diet allows you to have healthy carbs like berries and other lower glycemic foods on the carb list. You will need to put yourself back on the classic keto diet after 24-48 hours to get back into ketosis easily without all the adverse effects such as “keto flu.”

High Protein Ketogenic Diet
This variation is targeted more towards people struggling with obesity. In a high protein ketogenic diet, practitioners will consume 35% protein, 60% fat, and 5% carbs. The carbs are still kept low, but in this case, the fat is decreased by 15%, and the corresponding increase in protein is 15%. Protein is vital on the keto diet, but too much of it will cause you to fall out of ketosis, as mentioned earlier. This variation is also suitable for elite athletes.

Restricted Ketogenic Diet
This is a restricted caloric version of the standard diet, and only 12 grams of carbohydrate per day are allowed. This diet is most often used in medical settings and most often in the cancer ward when someone is following a keto diet with their cancer treatments. It is a variation used with a three day fast. A 2010 study showed that a patient with a form of brain cancer had no signs of mutated brain tissue after two months on this diet. Medical professionals will not only monitor caloric intake, carbs, and ketosis, but specific ketone levels will need to be achieved.

I am not advocating ketogenic diets, just trying to create an informed environment. Please post questions in the forum area, and I will address each one.

Sign up for our newsletter before you leave! And, be sure to submit any questions or comments.
​
#ketogenic, #ketogenicdiets, #lowcarbohydrates
 

​"Targeted Ketogenic Diet" by Stephen Pearson is licensed under CC BY 2.0

 ​Approximately 10-20% of the U.S population suffers from magnesium deficiency. Many people do not care about their deficiencies, but deficiencies are at the root cause of many disorders and chronic illnesses. A lack of magnesium, for example, can adversely affect the heart, muscles, sleep, energy level, and feeling of well-being. Are you having trouble sleeping at night but are fatigued during the day? Do you have difficulty with digestion and are chronically constipated? You may be suffering from a magnesium deficiency.

What About Magnesium in Food?
Magnesium levels in food have declined by 80-90% according to some research. That means getting magnesium from food unless it is added, is difficult. Also, many medications, such as a popular antacid, Omeprazole, causes low magnesium levels.

Won't Magnesium Deficiency be Corrected with a Multivitamin?
Couple a low intake with drug-nutrient interactions with a medical profession not trained to monitor magnesium levels when warranted, and we have a population deficiency problem that can easily be corrected through supplementation. In most cases, your One- A- Day won't do it, however. A scrupulous look at your multivitamin label will often find magnesium lacking. The reason it is often not included is it overpowers the smaller minerals also needed by the body like selenium. So, read the label before you feel confident your multivitamin is meeting your magnesium needs.

Forms of Magnesium
Magnesium comes bound to another molecule, which affects how well it is absorbed and the action of the molecule in the body. Examples include:

Magnesium sulfate: Found abundantly in Epsom salts, it has good absorption with low toxicity. It is terrific for tissue application and is absorbed well through the skin. It is used intravenously to prevent preterm labor, for bronchospasm, acute nephritis, and toxemia of pregnancy.

Magnesium Glycinate: This form of magnesium is one of the gentlest on the stomach. It is this form that is used for those recovering from bariatric surgery as it is the best absorbed and is also the supplement of choice for those recovering from low blood levels. It is the ideal form of magnesium for those who can not tolerate the laxative effects of magnesium oxide or magnesium citrate. Glycine, the molecule bound to magnesium, has a calming effect on the nerves and is supportive of cognitive function. It is often the form used for migraine headaches.

Magnesium L-Threonate: This is a newer form of magnesium and research is showing it to have a cognitive and neuropathic advantage in the animal model. The fact that this form of magnesium restored memory to aging rodents poses possible applications at a clinical level that need to be studied further.

It is the only form of magnesium that has been shown to penetrate the blood-brain barrier, thus directly raising brain magnesium levels. Anecdotal evidence suggests that magnesium L-threonate may help get rid of "brain fog" and helps with vestibular migraine. The downside is it is expensive and new and needs further research.

Magnesium Malate: Most commonly used form for fibromyalgia and chronic fatigue syndrome. It is said to have a high bioavailability, supports energy production, and the ability to chelate toxic metals. Malate also creates less gastrointestinal stress and irritation than oxide and citrate. It may be too energizing for some.

Magnesium Citrate: It is excellent for relieving Constipation. It is not as bioavailable as the other forms of magnesium.

Magnesium Oxide: Not very bioavailable and is used most frequently as a laxative or for heartburn.

What is the Dosage for Magnesium?
Most experts agree that 3-4 mg/kg/day will replete magnesium levels. However, keep in mind, though, that the recommended daily intake for adults for magnesium is between 310-400 mg per day depending on age and sex, so this repletion dosage may be on the low side for some. Repletion can be done based on conditions as below:

*Cluster headache: 1 gram of magnesium
*Vasoplastic Angina: 65 mg/kg given by IV
*Constipation: 8.75-25 g of magnesium citrate in a 150 ml to 300 ml solution
*Indigestion: 400-1200 mg of magnesium hydroxide up to 4x per day; 800 mg of magnesium oxide may also be used
Low blood levels: 3 grams of magnesium sulfate taken every 6 hours for 4 doses according to one reference. A glycinate version would probably be more effective. A 5% solution of magnesium chloride for 16 weeks may be used
*Heart disease: 800-1200 of magnesium oxide for three months
*Migraine: 400 mg/day

What are the Signs and Symptoms of Low Magnesium Levels?
· Irritability
· Muscle twitches or cramps
· Lethargy and fatigue
· Irregular heartbeats
· Dizziness
· Nausea and vomiting
· Numbness
· Personality changes
· Anxiety and panic attacks
· Insomnia
· High blood pressure
· Type 2 diabetes
· Osteoporosis
· Migraines
· Constipation
· Acid reflux
Foods High in Magnesium
· Avocados
· Leafy vegetables
· Cashews
· Tuna fish
· Flaxseeds
· Pumpkin seeds
· Dark chocolate
· Legumes
· Tofu
· Whole grains
· Fatty fish
· Bananas
· Soybeans
· Almonds

So, Do You Need Magnesium?
Magnesium deficiency is relatively common in clinical practice but goes mostly unrecognized due to a lack of testing. For example, low magnesium has been found in 84% of premenopausal women with Osteoporosis. Magnesium deficiency may persist despite normal serum levels. It has been suggested that the lower limit of normal for serum magnesium references an early deficiency. Measuring red blood cell magnesium is more accurate than serum magnesium.

What are the high-risk groups for low magnesium?
· Athletes
· Those with digestive or absorption issues
· Alcoholics
· Those over 60
· Those on proton pump inhibitors such as Omeprazole
· Those with diabetes

If you are experiencing symptoms such as those in the list above and are in one of the high-risk groups listed, you may be at risk for magnesium deficiency. Wouldn't it be great if you could start sleeping better and have more energy just by taking a supplement or changing your diet?
​
Need help finding quality magnesium products? Shop at Nutritional Synergy Clinic's Dispensary at https://us.fullscript.com/welcome/kshattler

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#magnesium, #hypomagnesaemia, #chronicfatiguesyndrome, #insomnia, #magnesiumsupplements, #magnesiumdeficiency

Alzheimer's Disease (AD), a brain disorder that ravages your memory, robbed 5.5 million Americans of their quality of life in 2019. Two-thirds of those affected were women, the traditional caretakers of our society. African Americans are twice as likely as Caucasians to be diagnosed with this illness, and there is no cure. But there is hope.
Research is showing that diet may delay the signs and symptoms of Alzheimer's Disease, and we all know that every moment we can spend with our loved one where we don't have to wrestle with the side-effects of this disease are precious and to be treasured.

Studies from Rush University in Chicago have found that the MIND diet, a combination of the DASH diet and the Mediterranean diet, may decrease the risk of Alzheimer's by as much as 50% and can still protect the brain even when not followed rigorously.

What is the MIND Diet?
The MIND diet was born out of blending the DASH diet for hypertension, which focused on limiting sodium in the diet while increasing vegetables and low-fat dairy with the Mediterranean diet. The Mediterranean Diet, a diet focused on increasing consumption of vegetables, monounsaturated fats from olive oil, fish, whole grains, and omega-3 fatty acids- the building blocks of this meal plan.

Researchers believe that those who follow the diet for years will receive the most significant protective benefits. The time to start a MIND diet is when you find out you have Alzheimer's Disease in the family as it will lower your risk of developing it. For those who already have it, it's not too late to start the diet to delay the progression of AD.

What Does the MIND Diet Do?
The MIND diet emphasizes those foods that protect the brain and restricts those foods that affect the brain adversely. It works because it reduces inflammation of the brain and nerves; it acts as an antioxidant for the tissues it makes nerve transmission more fluid and decreases neuron loss while improving memory overall.

How Do I Follow a MIND Diet?
As with any major change, start slow. Make a few changes at a time until the MIND diet feels like your everyday routine. Soon even grocery shopping will become automatic, and you won't have to pour over lists of foods that you aren't used to eating or learning new recipes or ways of cooking because it has become a habit. It just takes a little time, one step at a time.

When introducing starchy beans into the diet, do so slowly if it is a new food to the individual. Starchy beans like chickpeas, lentils, kidney beans, fava beans, etc., are not only high in fiber, they may be gas forming and cause bloating if introduced into the diet too quickly. Always introduce increased fiber slowly with 8 glasses of water per day to avoid bloating.

 Another trick to lessen gas and bloating from beans is to either soak them overnight, drain and rinse or bring to a boil and drain, rinse and then bring the beans to heat again. Draining the water gets rid of the gassy component present in beans.
Also, some healthy foods can be expensive, a real consideration for most of us. One way to save money is to buy fruits and vegetables in season and freeze them. Don't use sugar or salt, just freeze them after they've been cleaned, label and date them and freeze for later.

MIND Diet Guidelines

The Rules of the Diet Are:

• Get at least three servings of whole grains per day.
• Eat a salad each day.
• Eat one other vegetable every day.
• Drink a glass of wine each day.
• Snack almost every day on nuts.
• Eat beans every other day.
• Consume poultry and berries at least twice a week.
• Consume fish at least once a week.

The Five Unhealthy Foods Are:

• Fried or fast food
• Cheese
• Red meats
• Pastries and sweets
• Butter and stick margarine

For a detailed guide for beginners, go here.

Application
The MIND diet supports vascular health and is protective against vascular dementia. Certain foods used in the MIND diet have been directly linked to improved neurological function or reduced Alzheimer's Disease biomarkers in the brain. MIND diet foods reflect nutrients that have been shown in studies to slow cognitive decline, decrease the risk of AD, scour the brain of amyloid plaque, and decrease neuron loss.
​
So, while a cure may not be here, hope is on the horizon for a better quality of life by following the MIND diet.



​#Alzheimer's Disease #MIND diet #cognitive  #dementia

What is Evidence-Based Medicine?
Defined, evidence-based medicine is the cumulative result of a synthesis of clinical expertise, patient’s values and the best scientific evidence we have available relative to that patient’s care. Evidence-based medicine (EBM) originated in the second half of the 19th century and represents the conscientious use of the best evidence available in making reasonable decisions about patient care.

Gaps Between Research and Practice in   Medicine
One of the biggest shortcomings of using EBM is the gap between the release of scientific studies and their adoption by the clinical community. It represents a huge knowledge gap and a barrier to the implementation of the EBM model. For example, in the case of the beneficial use of aspirin in the treatment of heart attack victims, it took almost a decade for it to become a routine practice after the EBM studies were released.

Interestingly, the publication of COVID-19 articles are bypassing some of the usual publication rules  and are going right into the search engines. This is to specifically reduce the gap between research and practice, an endeavor much needed in this pandemic.

Classification of Evidence
EBM classifies evidence based on their freedom from biases in the interpretation of the results. The levels of evidence look something like this:
1.       Evidence obtained by a meta-analysis of several randomized controlled research (RCR).
2.       Evidence from a sole RCR.
3.       Evidence from one well designed controlled RCR.
4.       Evidence from one quasi-experimental approach.
5.       Research case study only.
6.       Evidence from one’s clinical practice or case studies.

Each level represents a strength of evidence to ponder in application to a patient’s case or to a public health situation. With EBM a provider can assess the strength of evidence with the risks/benefits of ordering tests and treatments for an individual patient or the strength of evidence for a public health recommendation.  We are said to be in an age of EBM.

Five Ways Evidence-Based Medicine Adds Value to the Functional Health Model
1.       EBM helps functional health providers stay on top of standardized treatment protocols without reading 17 studies a day by utilizing study classification and priority.
2.       Uses timely data to make decisions. This has been greatly aided by the computer age and the development and maintenance of large databases of information that providers can access for research and education.
3.       It improves accountability, transparency, and worth. What this means is the patient acquires the best care for the least cost with all variables of the treatment consistent with the values of the patient.
4.       Improves the quality of care. Despite the fact that Americans spend more money on healthcare than any other nation in the world, we are the sickest.
5.       Improves outcomes. Functional health providers are invested in practicing medicine that works, not just seeing patients on a daily schedule and taking care of urgent ills. They want to see that a prescribed treatment has true value for a patient and that the care received has made a significant impact on that patient’s overall health and well-being.
​
Functional health represents a fusion of EBM and alternative medicine. It has been argued that functional health practitioners are not evidence-based practitioners. That cannot be further from the truth. Functional health practitioners frequently rely on EBM for treatment decisions and novel approaches to diseases that are on the cutting edge of scientific decisions and novel approaches to diseases.

#evidence-based medicine #EBM  #quality control  #functional health  #evidence

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Berberine is a chemical found in several plants including the European barberry, goldenseal, goldthread, Oregon grape, philodendron, and tree turmeric and belongs to a class of compounds called alkaloids.

​ It is said to have powerful effects similar to that of a pharmacological nature and has been used for centuries in Chinese medicine. It is just now coming of age in modern nutritional medicine in the treatment of diseases such as diabetes.

How Does Berberine Work? Berberine is known to stimulate insulin secretion and to activate AMPK, an enzyme known to regulate cellular energy metabolism. Its primary actions are to:

• Decrease insulin resistance, making the blood sugar-lowering hormone insulin more effective.
• Increase glycolysis helping the body break down sugars inside cells.
•  Decrease in sugar production in the liver.
• Slow the breakdown of carbohydrates in the gut.
• Increase the number of beneficial bacteria in the gut without systemic activity by promoting the growth of good bacteria in the gut and halting the growth of bad bacteria.·       ·         

Activation of AMPK by pharmacological agents is known to reduce the metabolic effects of diabetes, an action also simulated by berberine.

Effectiveness of Berberine in Diabetic Patients: Berberine has been found to act in a similar manner as the commonly used diabetes drug Metformin. It is not clear whether metformin and berberine undertake all actions via the same mechanisms, or some via similar and other different mechanisms. While the severe adverse gastrointestinal side-effects that interfere with metformin compliance are generally absent in berberine treatment, treatment with both berberine and metformin (or other oral hypoglycemics) has been found to be superior in controlling glucose than either treatment alone.

Dosage and treatment duration may vary with the patient’s age. Data suggests that berberine therapy becomes unremarkable in treatments lasting more than 90 days or in amounts greater than 2 grams. Further clinical studies of longer duration are needed in this area. The most effective dose is 500 mg three times a day.

Because most anti-diabetic drugs cannot be used in patients with hepatic dysfunction, renal disease, and heart disease, this makes pharmacological therapy of type 2 diabetes complicated and the use of other nutraceuticals such as berberine more desirable.

Current studies have reported the significance of berberine against oxidative stress and inflammation in cells, elaborating its vital role in diabetes mellitus. Generally, a decrease in blood glucose level by 20%–40% is reported in fasting patients treated with berberine alone, this effect resembles that of rosiglitazone and metformin treatment.

Application:  Preliminary research from both animal and human studies indicate that berberine therapy in dosages of 500 mg three times per day may be an advantageous treatment for diabetes type 2 either alone or in conjunction with other hypoglycemics for optimal blood sugar control with minimal adverse side-effects.

The mechanisms of action of berberine mirror those of the common anti-diabetic drug metformin without the severe diarrhea side-effects that adversely affect medication compliance.

Further long-term studies are needed on human subjects to identify exact mechanisms of action and duration of treatment best utilized for long term blood sugar control of diabetes.

​#berberine #AMPK #diabetes #blood sugar #type 2 diabetes  #metformin
 
 
 
​These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.